| 1
| Bailey, Dylan | SO | Northeast (SP) | 4:30.77 | Richard Allen Invitational | Feb 26, 2021 |
| 2
| Stone, William | JR | Osceola (Seminole) | 4:36.75 | East Lake Early Bird Invitational | Feb 18, 2021 |
| 3
| Tenore, Frank | JR | St. Petersburg | 4:39.85 | St. Petersburg City Championship 2021 | Feb 20, 2021 |
| 4
| Forbes, Nickolas | FR | St. Petersburg | 4:52.52 | Richard Allen Invitational | Feb 26, 2021 |
| 5
| Fictum, Jeremiah | SO | Northeast (SP) | 4:52.80 | Shorecrest Chargers Invitational | Feb 25, 2021 |
| 6
| Hunsinger, Nason | JR | Northeast (SP) | 4:53.62 | Shorecrest Chargers Invitational | Feb 25, 2021 |
| 7
| D'Angio, Wes | SO | Osceola (Seminole) | 4:55.60 | 48th RAM Invite 2021 | Feb 27, 2021 |
| 8
| Laue, Ethan | SO | Seminole | 4:57.22 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 |
| 9
| Jensen, David | JR | Osceola (Seminole) | 4:57.46 | East Lake Early Bird Invitational | Feb 18, 2021 |
| 10 | Olsen, Hunter | SR | Seminole | 4:57.49 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 |
| 11 | Cappelli, Patrick | JR | Osceola (Seminole) | 4:58.62 | IMG Academy Invitational Fueled By Gatorade | Feb 20, 2021 |
| 12 | Zuppa, Eli | FR | Northeast (SP) | 4:59.34 | Shorecrest Chargers Invitational | Feb 25, 2021 |
| 13 | Reynolds, Avery | FR | St. Petersburg | 4:59.75 | Richard Allen Invitational | Feb 26, 2021 |
| 14 | Irby, Jay | JR | St. Petersburg | 5:00.54 | Richard Allen Invitational | Feb 26, 2021 |
| 15 | McManus, Ian | JR | Osceola (Seminole) | 5:03.11 | East Lake Early Bird Invitational | Feb 18, 2021 |
| 16 | Foster, Adam | FR | Osceola (Seminole) | 5:06.53 | Shorecrest Chargers Invitational | Feb 25, 2021 |
| 17 | Rubaii, Aaron | JR | Osceola (Seminole) | 5:07.01 | IMG Academy Invitational Fueled By Gatorade | Feb 20, 2021 |
| 18 | Wynne, Thomas | SR | Osceola (Seminole) | 5:13.67 | IMG Academy Invitational Fueled By Gatorade | Feb 20, 2021 |
| 19 | Cisliek, Eric | JR | Osceola (Seminole) | 5:13.89 | IMG Academy Invitational Fueled By Gatorade | Feb 20, 2021 |
| 20 | Laue, Conor | SR | Seminole | 5:16.99 | Richard Allen Invitational | Feb 26, 2021 |
| 21 | Laperriere, Keenan | SO | Seminole | 5:19.69 | Richard Allen Invitational | Feb 26, 2021 |
| 22 | Bloznalis, Julius | SR | Clearwater | 5:19.87 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 |
| 23 | Feger, Dylan | FR | Osceola (Seminole) | 5:20.09 | Shorecrest Chargers Invitational | Feb 25, 2021 |
| 24 | Dauval, Walker | FR | Osceola (Seminole) | 5:20.91 | Shorecrest Chargers Invitational | Feb 25, 2021 |
| 25 | Kasson, Jack | JR | Osceola (Seminole) | 5:26.11 | IMG Academy Invitational Fueled By Gatorade | Feb 20, 2021 |
| 26 | LaGrande, Chase | JR | Osceola (Seminole) | 5:26.45 | IMG Academy Invitational Fueled By Gatorade | Feb 20, 2021 |
| 27 | Foster, Louis | FR | Osceola (Seminole) | 5:27.28 | Shorecrest Chargers Invitational | Feb 25, 2021 |
| 28 | Elia, Frederick | SR | Northeast (SP) | 5:31.89 | Shorecrest Chargers Invitational | Feb 25, 2021 |
| 29 | Graves, Latham | FR | Osceola (Seminole) | 5:32.06 | East Lake Early Bird Invitational | Feb 18, 2021 |
| 30 | Escardo, Rodrigo | JR | Osceola (Seminole) | 5:36.65 | East Lake Early Bird Invitational | Feb 18, 2021 |
| 31 | Farrell, Jayson | SR | Clearwater | 5:37.86 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 |
| 32 | Vigue, Nolan | FR | Boca Ciega | 5:38.01 | Richard Allen Invitational | Feb 26, 2021 |
| 33 | Mahoney, Brendan | JR | Clearwater | 5:38.34 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 |
| 34 | WILSON, GRANT | FR | Osceola (Seminole) | 5:42.68 | East Lake Early Bird Invitational | Feb 18, 2021 |
| 35 | Siegel, Andrew | FR | Seminole | 5:44.19 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 |
| 36 | Santana, Anthony | FR | Countryside | 5:46.33 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 |
| 37 | Budo, Lawrence | FR | Boca Ciega | 5:47.72 | Richard Allen Invitational | Feb 26, 2021 |
| 38 | Phu, Skylar | FR | Seminole | 5:47.81 | Richard Allen Invitational | Feb 26, 2021 |
| 39 | Keleske, Timothy | JR | Clearwater | 5:52.09 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 |
| 40 | SIRABELLA, LUGINO | FR | Osceola (Seminole) | 5:54.98 | East Lake Early Bird Invitational | Feb 18, 2021 |
| 41 | Gregory, Mitchell | FR | Countryside | 6:00.23 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 |
| 42 | Ward, Joshua | JR | Osceola (Seminole) | 6:02.18 | East Lake Early Bird Invitational | Feb 18, 2021 |
| 43 | Mishchenko, Alexander | SO | Clearwater | 6:03.98 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 |
| 44 | BEGLEITER, SEAN | SO | Osceola (Seminole) | 6:05.93 | East Lake Early Bird Invitational | Feb 18, 2021 |
| 45 | Rice, Jake | SO | Seminole | 6:09.78 | Richard Allen Invitational | Feb 26, 2021 |
| 46 | Fahad, Al | SR | Boca Ciega | 6:11.22 | Richard Allen Invitational | Feb 26, 2021 |
| 47 | Schueler, Jayden | JR | Clearwater | 6:15.59 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 |
| 48 | Miller, Trevor | SO | Osceola (Seminole) | 6:20.42 | East Lake Early Bird Invitational | Feb 18, 2021 |
| 49 | Rivera-Vaughn, Jose | FR | Boca Ciega | 6:25.72 | Richard Allen Invitational | Feb 26, 2021 |
| 50 | Richard, Eli | FR | St. Petersburg | 6:25.77 | Richard Allen Invitational | Feb 26, 2021 |
| 51 | Rice, Jaye | SO | Seminole | 6:31.11 | Richard Allen Invitational | Feb 26, 2021 |
| 52 | Black, Brendan | SO | Seminole | 6:36.32 | Richard Allen Invitational | Feb 26, 2021 |
| 53 | Waring, Brooke | SO | Boca Ciega | 6:42.41 | St. Petersburg City Championship 2021 | Feb 20, 2021 |
| 54 | Figard, Kaleb | SO | Pinellas Park | 6:42.94 | Richard Allen Invitational | Feb 26, 2021 |
| 55 | Most, Jaden | FR | Boca Ciega | 6:45.54 | Richard Allen Invitational | Feb 26, 2021 |
| 56 | Brown, Jalen | SO | Countryside | 6:45.96 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 |
| 57 | Rosales, Jesus | FR | Boca Ciega | 6:53.10 | Richard Allen Invitational | Feb 26, 2021 |
| 58 | Polanco, Armando | SR | St. Petersburg | 7:03.21 | Richard Allen Invitational | Feb 26, 2021 |
| 59 | Andry, Kellan | SO | St. Petersburg | 7:08.82 | Richard Allen Invitational | Feb 26, 2021 |
