| 1
| Erby, Joel | SR | St. Stephens Episcopal | 11.61 | Shorecrest Chargers Invitational | Feb 25, 2021 | 0.8 |
| 1
| Moritz, Tomek | JR | Shorecrest Prep | 11.61 | Shorecrest Chargers Invitational | Feb 25, 2021 | 0.8 |
| 3
| McClellan, Usir | JR | Admiral Farragut | 11.63 | Shorecrest Invitational | Feb 18, 2021 | |
| 4
| Oleksak, John | SR | Indian Rocks Christian | 11.64 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.2 |
| 5
| Hinton, Jervon | JR | Admiral Farragut | 11.69 | St. Petersburg City Championship 2021 | Feb 20, 2021 | -1.1 |
| 6
| Krampert, Javon | SR | Indian Rocks Christian | 11.72 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.1 |
| 7
| Whyte, Mikhail | JR | Shorecrest Prep | 11.74 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.1 |
| 8
| Cheedy, Jacobi | SO | Admiral Farragut | 11.80 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 | |
| 9
| White, Ronald | SR | Admiral Farragut | 11.84 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 | |
| 10 | Rosenthal, LIncoln | SR | Keswick Christian | 11.85 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 0.7 |
| 11 | Bush, Brett | JR | Indian Rocks Christian | 11.91 | Shorecrest Chargers Invitational | Feb 25, 2021 | 0.6 |
| 12 | Hairston, Julian | JR | Shorecrest Prep | 11.92 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | +0.0 |
| 13 | Gabriel, Alexander | JR | Indian Rocks Christian | 11.93 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 0.7 |
| 14 | Konkol, Michael | SO | St. Stephens Episcopal | 12.04 | Shorecrest Chargers Invitational | Feb 25, 2021 | 1.9 |
| 15 | Lathrop, Chase | FR | Keswick Christian | 12.07 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.1 |
| 16 | Motwani, Sanjay | FR | St. Stephens Episcopal | 12.13 | Shorecrest Chargers Invitational | Feb 25, 2021 | 1.3 |
| 17 | Rawles, Louis | JR | St. Stephens Episcopal | 12.14 | Shorecrest Chargers Invitational | Feb 25, 2021 | 0.6 |
| 18 | Floto, James | SO | Shorecrest Prep | 12.16 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.1 |
| 19 | Krampert, Darian | SO | Indian Rocks Christian | 12.18 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 0.6 |
| 20 | Sherrill, Charlie | JR | St. Stephens Episcopal | 12.34 | Shorecrest Chargers Invitational | Feb 25, 2021 | 0.8 |
| 21 | Reese, Elijah | FR | Indian Rocks Christian | 12.42 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 0.6 |
| 22 | Konkol, Michael | JR | St. Stephens Episcopal | 12.50 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 23 | Coogle, Kai | JR | St. Stephens Episcopal | 12.51 | Shorecrest Chargers Invitational | Feb 25, 2021 | 1.3 |
| 23 | Sheikholeslam, Sean | SO | Shorecrest Prep | 12.51 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.3 |
| 25 | Dorta, Tyler | SO | Indian Rocks Christian | 12.57 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.2 |
| 26 | McMillen, Weston | FR | Indian Rocks Christian | 12.60 | Berkeley Track and Field Invitational | Feb 20, 2021 | 1.5 |
| 27 | Clark, DJ | SR | St. Stephens Episcopal | 12.70 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 28 | Faqqouseh, Nedim | JR | Out-of-Door | 12.83 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 28 | Thomas, Max | SR | Out-of-Door | 12.83 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 30 | Nemzek, Kyle | SO | St. Stephens Episcopal | 12.87 | Shorecrest Chargers Invitational | Feb 25, 2021 | 1.1 |
| 31 | Chang, Logan | FR | Shorecrest Prep | 12.89 | Shorecrest Chargers Invitational | Feb 25, 2021 | 0.5 |
| 31 | Hilton, Isaiah | SO | Admiral Farragut | 12.89 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 | |
| 31 | Mercer, Zackery | FR | Admiral Farragut | 12.89 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 | |
| 34 | Hutchinson, Nasir | 8
| Admiral Farragut | 12.91 | Shorecrest Invitational | Feb 18, 2021 | |
| 35 | Tulupov, Ivan | FR | St. Stephens Episcopal | 12.93 | Shorecrest Chargers Invitational | Feb 25, 2021 | 0.5 |
| 36 | Cullins, Prophet | JR | Indian Rocks Christian | 13.09 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | -1.2 |
| 37 | Evans, Shakeem | JR | Admiral Farragut | 13.13 | Shorecrest Invitational | Feb 18, 2021 | |
| 38 | Lazzara, Julian | 7
| St. Stephens Episcopal | 13.20 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 39 | Lueken , Max | JR | Shorecrest Prep | 13.34 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.3 |
| 40 | Nemzek, Kyle | JR | St. Stephens Episcopal | 13.45 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 41 | Tredo, John | SO | St. Petersburg Catholic | 13.51 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.1 |
| 42 | Groves, Noah | FR | Indian Rocks Christian | 13.52 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 0.7 |
| 43 | Spalding, Hadeon | FR | Shorecrest Prep | 13.66 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.3 |
| 44 | Kanaylo, Jordan | FR | Indian Rocks Christian | 13.67 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.7 |
| 45 | Douglas, Jacob | FR | Out-of-Door | 13.70 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 46 | Cher-Aime, Alex | JR | Bradenton Christian | 13.73 | 48th RAM Invite 2021 | Feb 27, 2021 | -1.1 |
| 47 | Waitz-Miller, Chase | SO | Shorecrest Prep | 13.76 | Shorecrest Chargers Invitational | Feb 25, 2021 | 1.9 |
| 48 | Els, Kyle | FR | Indian Rocks Christian | 13.79 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.2 |
| 49 | Decker, Conner | JR | Indian Rocks Christian | 13.83 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.3 |
| 50 | Valadie, Lance | SO | St. Stephens Episcopal | 13.91 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 51 | Stallo, Anthony | 7
| Indian Rocks Christian | 13.92 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 0.6 |
| 52 | Clarke, Joseph | FR | Out-of-Door | 13.96 | 48th RAM Invite 2021 | Feb 27, 2021 | -1.1 |
| 53 | Dempsey, Colten | 7
| Bradenton Christian | 14.04 | 48th RAM Invite 2021 | Feb 27, 2021 | -1.1 |
| 54 | Varga, Austin | 8
| St. Stephens Episcopal | 14.10 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 55 | Flagg, Ethan | FR | Indian Rocks Christian | 14.25 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.2 |
| 56 | Lam, Aidan | SR | St. Petersburg Catholic | 14.38 | Calvary Christian Warrior Invite 2021 | Feb 26, 2021 | |
| 57 | Puodzuinas, Algimantas | SO | St. Petersburg Catholic | 14.64 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.7 |
| 58 | Brown, Evan | FR | St. Stephens Episcopal | 14.68 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 59 | Conner, Jackson | JR | St. Stephens Episcopal | 14.82 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 60 | Ochoa, Matthew | FR | Indian Rocks Christian | 14.88 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | -1.2 |
| 61 | Stroh, Jeremy | 7
| St. Stephens Episcopal | 14.91 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 62 | Matthews, Daniel | FR | Indian Rocks Christian | 14.92 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | -1.2 |
| 63 | Ulrick, Mac | FR | Out-of-Door | 15.32 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 64 | Lindsay, George | 7
| St. Stephens Episcopal | 15.94 | SSES Quad Meet 1 | Feb 19, 2021 | |
| 65 | Mello, Harrison | 6
| Bradenton Christian | 16.68 | Manatee Hurricanes Invitational | Feb 19, 2021 | |
| 66 | Parrish, Codey | FR | Keswick Christian | 17.24 | Indian Rocks Sprint Series Meet 1 | Mar 1, 2021 | 1.1 |
| 67 | Dole, Cade | 6
| Bradenton Christian | 19.59 | Manatee Hurricanes Invitational | Feb 19, 2021 | |
