| 1
| Schulz, Andreas | JR | University (OC) | 23.80 | FHSAA 4A Region 1 | May 7, 2022 | 1.2 |
| 2
| Graham, Kamari | SO | Homestead | 24.74 | North Miami Invite Meet #1 | Feb 22, 2022 | |
| 3
| Ramirez, Relamp | SR | Lake Brantley | 25.08 | Sanford Seminole Invitational | Feb 25, 2022 | 1.2 |
| 4
| Jones, Giovanni | SO | Miami Carol City | 25.78 | FHSAA 2A Region 4 | May 5, 2022 | 2.2 |
| 5
| Washington , Tavares | SO | Miami Carol City | 25.81 | FHSAA Class 4A & Para Track & Field State Championships | May 14, 2022 | -0.4 |
| 6
| Jones, Marquis | SR | Miami Northwestern | 25.88 | FHSAA Class 4A & Para Track & Field State Championships | May 14, 2022 | -0.4 |
| 7
| Forgue-Luders, Edwin | SR | Lincoln Park | 27.71 | FHSAA 2A Region 2 | May 5, 2022 | 1.6 |
| 8
| Gold, Aaron | FR | Gulliver Prep | 29.88 | FHSAA 2A Region 4 | May 5, 2022 | 2.2 |
| 9
| Moore, Liam | FR | Miami Coral Park | 32.90 | FHSAA 4A Region 4 | May 7, 2022 | -1.1 |
| 10 | Pena, Aaron | SR | Sebastian River | 34.78 | FHSAA Class 4A & Para Track & Field State Championships | May 14, 2022 | 1.2 |
| 11 | Escolastico, Amir | JR | Braddock | 35.01 | FHSAA 4A District 16 | Apr 21, 2022 | 0.1 |
| 12 | Bolton, Brett | SO | Rockledge | 35.93 | FHSAA Class 4A & Para Track & Field State Championships | May 14, 2022 | -0.4 |
| 13 | Holman , Zacharey | SR | Frostproof | 36.20 | FHSAA Class 4A & Para Track & Field State Championships | May 14, 2022 | 1.2 |
| 14 | Mizrachi, Jonathan | SR | Coral Reef | 36.50 | Dunbar Tigers Guy Thomas Memorial Classic | Mar 26, 2022 | 0.6 |
| 15 | Moore, Chris | SR | Forest Hill | 43.93 | PBC Central Conference 2022 | Mar 28, 2022 | -1.1 |
| 16 | Knowles, Ashton | FR | Ed White | 51.80 | FHSAA Class 4A & Para Track & Field State Championships | May 14, 2022 | 1.2 |
| 17 | Joseph, Herwin | SO | Riverdale | 1:01.03 | FHSAA 4A District 8 | Apr 23, 2022 | |
