| 1
| Clark, C'ontrae | JR | Palatka | 11.01 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.3 |
| 2
| Goldwire, Ron'Darius | SR | Santa Fe | 11.18 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.3 |
| 3
| Walker, Ernest | SR | Eastside | 11.34 | Wildwood High School Invitational | Feb 27, 2021 | |
| 4
| Nelson, Q'juan | JR | Palatka | 11.43 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.3 |
| 4
| Wilson, Omarion | SR | Palatka | 11.43 | Mandarin Mustang Classic | Feb 27, 2021 | |
| 6
| Passmore, Roderris | JR | Palatka | 11.47 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.8 |
| 7
| Davis, Preston | FR | Menendez | 11.55 | Mandarin Mustang Classic | Feb 27, 2021 | |
| 8
| Dumas, Chavaris | SO | Interlachen | 11.57 | Ridgeview Panther Invitational | Feb 18, 2021 | 3.0 |
| 8
| Jones, Kohl | SR | Menendez | 11.57 | Mandarin Mustang Classic | Feb 27, 2021 | |
| 10 | White lll, Billy | JR | Santa Fe | 11.62 | Oak Hall School Mini Meet #2 | Feb 24, 2021 | |
| 11 | Spires, Trace | JR | Santa Fe | 11.64 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.3 |
| 12 | Kellum, Elijah | FR | P. K. Yonge | 11.65 | Oak Hall School Mini Meet #2 | Feb 24, 2021 | |
| 13 | Hudson, Borie | JR | Santa Fe | 11.66 | Oak Hall School Mini Meet #2 | Feb 24, 2021 | |
| 13 | Jordan, Seager | SR | Palatka | 11.66 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.5 |
| 15 | Williams, Michael | JR | Eastside | 11.67 | Wildwood High School Invitational | Feb 27, 2021 | |
| 16 | Robinson, Tyrique | SO | Santa Fe | 11.71 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.5 |
| 17 | Williams, Jamo | FR | Eastside | 11.76 | Wildwood High School Invitational | Feb 27, 2021 | |
| 18 | Robinson, Tommy | SO | Palatka | 11.78 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.8 |
| 19 | Wetherington, Connor | JR | Santa Fe | 11.79 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.9 |
| 20 | Smith, Lee'Trez | JR | Palatka | 11.87 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.1 |
| 21 | Evans, Javarus | SO | Santa Fe | 11.91 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.6 |
| 22 | Wright, Cedric | FR | Interlachen | 11.99 | Ron Riddle Invitational | Feb 26, 2021 | |
| 23 | Woddell, Johnny | 7
| Keystone Heights | 12.01 | Ridgeview Panther Invitational | Feb 18, 2021 | 3.2 |
| 24 | Bostic, Mahki | JR | Newberry | 12.11 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.8 |
| 25 | Mavin, Brenden | JR | Eastside | 12.19 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.1 |
| 26 | Butler, Aaron | SO | Menendez | 12.20 | Mandarin Mustang Classic | Feb 27, 2021 | |
| 26 | Newsome, Derrell | JR | Menendez | 12.20 | Ridgeview Panther Invitational | Feb 18, 2021 | 3.3 |
| 28 | Hopkins, Jared | FR | Fort White | 12.25 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.6 |
| 29 | Anderson, Ethan | JR | Eastside | 12.27 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.8 |
| 30 | Williams, Aundry | SO | Interlachen | 12.28 | Ron Riddle Invitational | Feb 26, 2021 | |
| 31 | Mack, Kriston | SO | Palatka | 12.31 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.8 |
| 32 | Johnson, Kaleb | SO | Santa Fe | 12.32 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.1 |
| 33 | Bello, David | FR | Newberry | 12.33 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.1 |
| 34 | Bush, Ty'Ran | SO | Interlachen | 12.35 | Ridgeview Panther Invitational | Feb 18, 2021 | 2.5 |
| 35 | Morton, Spencer | SO | Santa Fe | 12.37 | Oak Hall School Mini Meet #2 | Feb 24, 2021 | |
| 36 | Canty, Milton | JR | Interlachen | 12.38 | Ridgeview Panther Invitational | Feb 18, 2021 | 2.5 |
| 37 | Bach, Bryon | SR | Keystone Heights | 12.42 | Ridgeview Panther Invitational | Feb 18, 2021 | 2.5 |
| 38 | Ansted, Cole | SO | Newberry | 12.44 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.1 |
| 38 | Delima, Kobe | JR | Newberry | 12.44 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.8 |
| 40 | Bell, Kashon | JR | Menendez | 12.51 | Ridgeview Panther Invitational | Feb 18, 2021 | 3.3 |
| 41 | Haight, Brock | SO | Newberry | 12.55 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.9 |
| 42 | Capps, Tristan | FR | Fort White | 12.57 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.3 |
| 43 | Anzalone, Anthony | SO | Palatka | 12.58 | Ed White Mini Meet 2 | Feb 23, 2021 | |
| 43 | Hopkins, Josiah | 7
| Fort White | 12.58 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.1 |
| 45 | Mann, Jayden | FR | Eastside | 12.59 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.4 |
| 46 | Smith, Josh | JR | Menendez | 12.63 | Ridgeview Panther Invitational | Feb 18, 2021 | 3.2 |
| 47 | Godfrey, Arterian | FR | Palatka | 12.67 | Mandarin Mustang Classic | Feb 27, 2021 | |
| 48 | McCoy, Blake | FR | Santa Fe | 12.72 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.4 |
| 48 | Wang, Joshua | SO | Eastside | 12.72 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.6 |
| 50 | Durr, Raheem | SO | Santa Fe | 12.75 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.9 |
| 51 | Solomon, Swanzi | FR | Eastside | 12.77 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.8 |
| 52 | Snee, Timothy | SR | Newberry | 12.79 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.3 |
| 53 | Frazier, Kyan | SO | Eastside | 12.82 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.1 |
| 53 | Haughton, Diontay | JR | Fort White | 12.82 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.3 |
| 55 | Park, Jaden | FR | Keystone Heights | 12.91 | Ridgeview Panther Invitational | Feb 18, 2021 | 2.6 |
| 56 | Johnson, Maurice | SO | Eastside | 12.94 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.3 |
| 57 | Brown , Jeremiah | SR | Newberry | 13.00 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.6 |
| 57 | Eich, Kyler | SR | Santa Fe | 13.00 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.9 |
| 59 | Rivera, Fabin | SO | Newberry | 13.08 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.9 |
| 60 | Johnson, Holden | SO | Eastside | 13.18 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.2 |
| 61 | Ngambo, Jaskim | SO | Santa Fe | 13.22 | Oak Hall School Mini Meet #2 | Feb 24, 2021 | |
| 62 | Eastman, Bryan | SO | Newberry | 13.37 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.4 |
| 63 | Waters, Noel | SO | Eastside | 13.43 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.8 |
| 64 | Waldon, Ta Joun | FR | Eastside | 13.48 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.4 |
| 65 | Konen, Anthony | FR | Menendez | 13.53 | Mandarin Mustang Classic | Feb 27, 2021 | |
| 66 | Morant Jr, Javarius | 6
| P. K. Yonge | 13.64 | Oak Hall School Mini Meet #2 | Feb 24, 2021 | |
| 67 | Leach, Dakota | 7
| Keystone Heights | 14.00 | Ron Riddle Invitational | Feb 26, 2021 | |
| 68 | Amir, Etemadi | SO | Eastside | 14.01 | SFHS Mini Meet #1 | Feb 18, 2021 | 0.4 |
| 69 | Foye, Jahiem | JR | Santa Fe | 14.08 | Oak Hall School Mini Meet #2 | Feb 24, 2021 | |
| 70 | Tate, Teveon | SO | Newberry | 14.49 | SFHS Mini Meet #1 | Feb 18, 2021 | 1.8 |
